The Buddha famously said, “I have taught one thing and one thing only, dukkha [suffering or reactivity or a sense of unsatisfactoriness] and the cessation of dukkha.” In this daylong, we explore this core teaching as it is expressed in the Four Noble Truths and the teaching of the Two Arrows. We suggest ways to study and implement this teaching both in formal meditation and in everyday life, through practices and reflections that bring together the wisdom of seeing the roots of dukkha, the compassion and kindness that can hold our difficulties, and skillful action to transform dukkha.This talk give an orientation for the daylong.